Steroids and derivatives
Medchemexpress LLC Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-sulfamate | 172377-52-5 | MFCD00947822 | 351.46 | 100 MG
Estradiol 3-sulfamate, also known as E2MATE, is a potent, long-acting, and orally active steroid sulfatase inhibitor. It effectively inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM. This compound is transformed and absorbed in the gut into its oxidative metabolite, EMATE, both of which are strong steroid sulfatase inhibitors. It is intended for research use only.
- Potent, long-acting steroid sulfatase inhibitor
- Orally active
- Inhibits estrone sulfatase (IC50 of 251 nM)
- Shows growth inhibitory effects on various cancer cell lines
Apexbio Technology LLC α-Estradiol 57-91-0 50mg
alpha-Estradiol (57-91-0) is a small-molecule inhibitor targeting 5 -reductase the enzyme responsible for converting testosterone to dihydrotestosterone (DHT) It is designed to inhibit 5 -reductase activity thereby modulating androgen metabolism and androgen-related signaling pathways alpha-Estradiol exerts its biological activity primarily through enzyme inhibition In reported experimental studies alpha-Estradiol demonstrates inhibitory activity against 5 -reductase with an IC50 value ranging from approximately 1 to 10 M though the precise value may depend on assay conditions Based on these pharmacological properties alpha-Estradiol holds research potential in the treatment and study of androgenetic alopecia
eMolecules 79037-37-9 | Medchem Express | Estradiol-d3 | 1mg | 713707131 | HY-B0141S | MFCD01074033 | 275.406 | C18H24O2
Medchem Express | Estradiol-d3 | 1mg | 713707131 | HY-B0141S | 79037-37-9 | MFCD01074033 | 275.406 | C18H24O2
Apexbio Technology LLC Ethinyl Estradiol 57-63-6 10mM (in 1mL DMSO)
Ethinyl Estradiol (57-63-6) is a small-molecule estrogen receptor agonist targeting intracellular estrogen receptors It is designed to activate these receptors thereby regulating transcription of estrogen-responsive genes and influencing reproductive biology and cell proliferation pathways Ethinyl Estradiol exerts its biological activity primarily through direct binding to estrogen receptors leading to the modulation of endocrine-regulated mechanisms Based on these pharmacological properties Ethinyl Estradiol holds research potential in studies of receptor-mediated responses endocrine regulation mechanisms synthetic hormone interactions drug interactions contraceptive mechanisms and hormone-dependent physiological processes
Medchemexpress LLC Alpha-Estradiol | 57-91-0 | 99.9% | 5 G
Alpha-Estradiol is identified as a weak estrogen and a 5α-reductase inhibitor. It is employed as a topical medication for treating androgenic alopecia.
- Weak estrogen.
- Acts as a 5α-reductase inhibitor, preventing testosterone metabolism catalyzed by 5 alpha-reductase.
- Attenuates LPS-induced inflammatory markers in mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes, and differentiated 3T3-L1 adipocytes through an ERα-dependent mechanism.
- Decreases NFκB-p65 and elevates ERα protein expression.
- Significantly reduces the central avascular/total retina area in mouse pups.
- Lowers malondialdehyde (MDA) levels, the number of NADPH-oxidase-positive cells, NADPH oxidase concentration, and activity in the retinas of hyperoxia-exposed pups.
Medchemexpress LLC Estradiol dipropionate | 113-38-2 | 99.5% | 25 MG
Estradiol dipropionate is a combined estrogen-progesterone, functioning as an estrogen and progesterone agonist. It is intended for research use only.
- Acts as an estrogen and progesterone agonist.
- Used in research for studying uterine response to estradiol under the action of chorionic gonadotropin in mice.
Medchemexpress LLC Estradiol-d3 | 79037-37-9 | MFCD01074033 | 99.8% | 1 MG
Estradiol-d3 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
FUJIFILM BIOSCIENCES INC Digitonin
Digitonin is a spirostan saponin obtained from the seeds and leaves of digitalis D purpurea D lanata A mild nonionic detergent digitonin is used in a wide range of applications including solubilization of membrane proteins permeabilization of cellular membranes isolation of mitochondria and quantitation of cholesterol Water Soluble 4% For research use only RUO
TARGETMOL CHEMICALS INC Teklad Global 18% Protein Rodent Diet
Teklad Global 18% Protein Rodent Diet 998.0 + Standard Diet Base Cuprizone *Minimum order is 3kg. Price given is price per kg for a 3kg order. Price breaks at higher kg order amounts.
Medchemexpress LLC Estra-1,3,5(10)-triene-3,17-diol (17β)-, 17-(hydrogen butanedioate) | 7698-93-3 | 98.8% | 372.45 | 5 MG
Beta-Estradiol 17-hemisuccinate is a synthetic derivative of estradiol. It is provided as a white to off-white solid.
- Consistent with structure by 1H NMR and LCMS.
- High purity of 98.83% (LCMS).
- Store at 4°C under nitrogen for solid form.
- In solvent, store at -80°C for up to 6 months or -20°C for 1 month, both under nitrogen.